Post by thread:[OT]:: Sunlight exposure reduces breast cancer ris

A somewhat unexpected conclusion about sunlight exposure and breast cancer. This study supports the hypothesis that sunlight exposure reduces risk of advanced breast cancer among women with light skin pigmentation. Something that most light skinned women should be aware of. There are numerous apparently 'strange' health ideas around - this one has a better pedigree than many. http://aje.oxfordjournals.org/cgi/content/abstract/kwm259v1 American Journal of Epidemiology Advance Access Published online on October 12, 2007 Mechanism is thought to be (and may be) the increased Vitamin D levels generated by sunlight exposure. While some vitamin D is obtained from diet, about 90% of recommended level is generated by sunlight exposure. Guideline from the study: If you have a pale skin and a somewhat suntanned forehead compared to the skin colouration under your upper underarm then you are probably getting enough sunlight. Full text costs $. Russell ___________________________ http://aje.oxfordjournals.org/cgi/content/abstract/kwm259v1 American Journal of Epidemiology Advance Access published online on October 12, 2007 American Journal of Epidemiology, doi:10.1093/aje/kwm259 American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: spam_OUTjournals.permissionsTakeThisOuToxfordjournals.org. Original Contribution Sun Exposure, Vitamin D Receptor Gene Polymorphisms, and Breast Cancer Risk in a Multiethnic Population Esther M. John1,2, Gary G. Schwartz3, Jocelyn Koo1, Wei Wang4 and Sue A. Ingles4 1 Northern California Cancer Center, Fremont, CA 2 Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 3 Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University, Winston-Salem, NC 4 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA Correspondence to Dr. Esther M. John, Northern California Cancer Center, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538 (e-mail: .....ejohnKILLspam@spam@nccc.org ). Received for publication February 7, 2007. Accepted for publication July 26, 2007. Considerable evidence indicates that vitamin D may reduce the risk of several cancers, including breast cancer. This study examined associations of breast cancer with sun exposure, the principal source of vitamin D, and vitamin D receptor gene (VDR) polymorphisms (FokI, TaqI, BglI) in a population-based case-control study of Hispanic, African-American, and non-Hispanic White women aged 35–79 years from the San Francisco Bay Area of California (1995–2003). In-person interviews were obtained for 1,788 newly diagnosed cases and 2,129 controls. Skin pigmentation measurements were taken on the upper underarm (a sun-protected site that measures constitutive pigmentation) and on the forehead (a sun-exposed site) using reflectometry. Biospecimens were collected for a subset of the study population (814 cases, 910 controls). A high sun exposure index based on reflectometry was associated with reduced risk of advanced breast cancer among women with light constitutive skin pigmentation (odds ratio = 0.53, 95% confidence interval: 0.31, 0.91). The association did not vary with VDR genotype. No associations were found for women with medium or dark pigmentation. Localized breast cancer was not associated with sun exposure or VDR genotype. This study supports the hypothesis that sunlight exposure reduces risk of advanced breast cancer among women with light skin pigmentation. African Americans; breast neoplasms; Hispanic Americans; polymorphism, genetic; receptors, calcitrol; skin pigmentation; sunlight; vitamin D Abbreviations: CI, confidence interval; OR, odds ratio; VDR, vitamin D receptor; 25(OH)D, 25-hydroxyvitamin D (calcidiol); 1,25(OH)2D, 1,25-dihydroxyvitamin D (calcitriol)